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CHIRAL CATALYSTS AND SCREENING

Chiral Quest provides ‘kits’ containing a broad array of catalysts for rapid evaluation on a research scale by our customer. After a particular catalyst is selected for scale-up, Chiral Quest supports the customer with supply of grams-to-kilo quantities for commercial manufacture. We have practical manufacturing processes for five catalysts.

Customers benefit from our expertise in developing the optimum process for introduction of a chiral center. When they provide proprietary targets, we screen catalysts and reaction conditions to define the optimal process.

This screening service can be as simple as identifying a catalyst that provides the target chiral purity, or as complex as a fully developed commercial process ready for technology transfer to manufacturing.

Chiral Quest has developed and commercialized five asymmetric hydrogenation ligands and their respective catalysts:

  • C3-TunePhos
  • DuanPhos
  • TangPhos
  • Binapine
  • Binaphane
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Chiral Quest provides a ‘Catalyst Kit’ for evaluation. These catalysts are air-stable, and can be weighed and handled without a glove-box.

The catalyst kit includes 200 mgs each of the following catalysts:

  • [RuCl((R)-C3-TunePhos)(P-Cymene)]Cl
  • Rh((1S,1S’,2R,2R’)-TangPhos)(COD)BF4
  • Rh((S)-BINAPINE)(COD)BF4
  • Rh((R)-BINAPHANE)(COD)BF4
  • Rh((1R,1R’,2S,2S’)-DuanPhos)(COD)BF4
Click here for additional technical information
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